Human Plasma Leptin in Obese Subjects and Diabetics.
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چکیده
منابع مشابه
Plasma Leptin in Obese Subjects and Diabetics
Leptin is the protein product of the ob gene, an adipocyte-specific gene, recently discovered in mice. Plasma leptin levels were determined in six normals, twenty-one subjects with impaired glucose tolerance, and forty-nine untreated NIDDM subjects. They increased with the augmentation of obesity (body mass index, BMI kg/m2) and were higher in females than in males: in BMI less than 25 kg/m2 th...
متن کاملPlasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance.
OBJECTIVE Adipose tIssue regulates insulin sensitivity via the circulating adipocytokines, leptin, resistin and adiponectin. The objective of this study was to compare the levels of resistin, adiponectin and leptin in lean and obese subjects and determine the relationship between circulating adipocytokines and insulin resistance. METHODS We examined plasma levels of resistin, adiponectin and ...
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it has previously been demonstrated that circulating levels of leptin show ethnic differences when controlled for the confounding influence of adiposity. this study examined leptin levels in non-obese and obese subjects with type 2 diabetes of african versus caucasian origin. materials and methods non-obese and obese subjects with type 2 diabetes of either african origin living in dar es salaam...
متن کاملPlasma leptin and insulin relationships in obese and nonobese humans.
Hyperinsulinemia. is associated with an overexpression of mRNA for the ob protein leptin in rodent models of genetic obesity, and insulin has been reported to directly stimulate leptin mRNA in rat adipocytes. Human obesity is also associated with increased leptin mRNA as well as plasma levels, but there have been no reports of the effect of insulin on leptin secretion. We, therefore, tested the...
متن کاملExperimental and clinical studies on plasma leptin in obese dogs.
Leptin is a protein synthesized and secreted primarily by adipocytes, and the circulating leptin concentration is elevated in obese humans and rodents. Recently, we have established a sandwich enzyme-linked immunosorbent assay for canine leptin. In the present study, plasma leptin concentrations were measured in experimentally developed obese beagles and in clinically obese dogs. When 5 male be...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 1997
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.44.671